Posted by: Shirley-Arkansas-USA ®
06/20/2003, 21:37:45
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Hey my friend,
I thought that Botox "left the body" also. Can't imagine it being stored somewhere. We know that it stops working after a period of time.
I really don't remember anyone specifically talking about this before.
You could always go to the www.botox.com site and they have a place where you can email questions and they will respond to them. It sometimes takes them awhile to get back to you but they have always answered my questions. This would be a good one for them to answer.If you do contact them and get a response, let us know. Shirley in Arkansas
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Posted by: Joanne Matuzas ®
06/27/2003, 00:07:23
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Here's the response from Allergan about how Botox is metabolized.
The drug is a neurotoxin and binds intracellulary at the nerve endings that activate voluntary muscles. After initial absorption following injections, the surrounding parts of the molecule (the non-toxin part),
are rapidly excreted in the urine within 24 hours.
The active toxin binds inside the local nerve endings where it was injected which is where it inhibits the chemical needed for muscle movement. Botox is not considered a systemic drug that actively circulates in the body. After approx. 12 to 16 weeks, the nerve endings are able to produce the chemical needed to activate the muscle, and muscle activity returns.
Not sure this answer is complete but there it is...
Joanne M. San Diego, CA
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Posted by: Sally - in - Idaho ®
06/27/2003, 15:22:38
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Very interesting, Joanne. Thanks for searching out an answer. Maybe someone at the conference will elaborate a bit more on it.How have you been? Do you have a dog yet? Sally in HOT North Idaho
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Posted by: Joanne Matuzas ®
06/29/2003, 23:47:05
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Hi Sally--doing ok, just dealing with this disorder as the rest
of us....searching for answers to our changing challenges!!It's been two years and no doggie yet....While I am still employed,
heading up the San Diego support group and have lots on my plate, I'm waiting a bit--but will do one of these days hopefully in the not to distant future. Can't believe it's been two years since my golden passed on. He still lives in my heart though!! Thanks for asking and caring....Joanne M. San Diego, CA
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Posted by: Nancy in B.C. ®
06/30/2003, 23:21:33
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Thanks for looking into that Joanne. I was wondering about that myself, because after the last two treatments with botox, about one month later, I have come down with some mysterious pains, once behind the left shoulder blade, and secondly in the back /hip on the left side. It's very sharp, nerve-like pain which has disappeared after a week, thankfully. Sounds like it should not be caused by Botox, but whenever something new pops up it makes me wonder what the connection is. Nancy
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Posted by: APhair ®
06/29/2003, 13:52:40
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Hi Joanne. Nice to hear from you again. By the way, are you going to make it to the conference in Philly this year. It would be nice seeing you again. As for the botox being stored in the body, I don't know the real answer other than if it was, many of us who have been taking it wfor years would probably be dead by now. Seeing as it doesn't work much for my eyes anyway, maybe it will help somewhereelse int he body if it does hang around....Alan
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Posted by: Mary, upstateNY ®
06/29/2003, 20:11:14
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Alan - The way I see it, considering the current "Botulinum" scare, i.e., WMD from Saddam, those of us who have been having Botox for many years have nothing to worry about -- we're probably immune to any attacks from terrorists! Mary
P.S.I'm confident that your recent "re-dip" in the pool will get Shirley back on more often! See you in Philly.
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Posted by: Lynn Yarbrough ®
07/01/2003, 13:47:11
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I hope you are just kidding -- AFAIK you cannot build up an immunity to Botulism. The only thing that saves us Botox users is our dosage size, which is microscopic. My understanding is that a lethal human dose is around 3000 MU, while a typical BEB dose is under 100 MU. (One MU is what it takes to kill a laboratory mouse, 50% of the time.) Botulism is still a problem in that it can be created from natural sources like poorly canned tomatoes, etc. Of course, we should be glad that we can't build up such an immunity, since it would destroy the effectiveness of our currently most powerful weapon aganst BEB.--- Lynn
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Posted by: Joanne Matuzas ®
06/29/2003, 23:54:17
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Thanks Alan. Hope to make the conference but not sure yet--other
side of the country and timing...Will let you know.
I like your assessment with regard to botox being stored in the
body!! Makes good sense.
Take care and regards to Jan.
Joanne M. San Diego, CA
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Posted by: Delaine Inman in TN ®
07/03/2003, 10:38:59
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I know what the "experts and Botox company" says about how Botox is absorbed and not absorbed, but my common nursing sense knows that even topical ointments are absorbed somewhat into the skin and the skin contains blood vessels. Anything placed into the body by any means or method is absorbed somewhat into the cells and tissue which have a blood supply or they wouldn't be living tissue. Some is absorbed into the system and the potential side effects are admission of that. Even the ones not mentioned but things we know from experience tells me that yes it is in our system. We just get small doses. If we have to have it to open our eyes the risk at this time is worth the results for me. Like most of you, I don't want any more than I have to have to get results and no more frequently than necessary. But we know it disperses to areas it is not injected and it does get in our entire blood supply in very small amounts, sometimes not even measurable. You can't isolate it, the body doesn't work that way. Each part affects the whole. All is connected.
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Posted by: Joanne Matuzas ®
07/03/2003, 14:19:34
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Thank you all for your responses and input. There is really no one
specific answer to the question and as we know all too well, everyone's body is affected differently as a result of the botox injections.
Delaine did a nice job of encapsulating the issue with the conclusion
that our body is interconnected and one part in some small way, does affect the whole. Joanne M. San Diego, CA
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